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Merck Principal Scientist in Helena, Montana

Job Description

Short description:

Principal Scientist to evaluate the safety of mutagenic and non-mutagenic impurities as well as perform in silico assessments to characterize mutagenic potential of metabolites and molecules in early discovery.

Position Description:

The Impurity Strategy and In Silico Genetic Toxicology group within the ADME/Discovery Toxicology organization is seeking an office-based Principal Scientist with expertise in impurity risk assessment (e.g., addressing recommendations in ICH Q3A, Q3B, Q3C, Q3D, and/or ICH M7) and conducting in silico assessments to investigate mutagenic/genotoxic potential. The candidate will also contribute to development of derisking strategies for potentially genotoxic metabolites and molecules in early discovery. The candidate will be expected to work collaboratively with scientists from Nonclinical Drug Safety, medicinal chemistry, ADME, process chemistry, analytical chemistry, and regulatory affairs-CMC. Other responsibilities include development of genetic toxicology testing strategies related to impurity risk assessment as well as participation in external working groups and consortia.

Minimum required education:

Ph.D. in Toxicology or Chemistry, or related discipline, with post-doctoral and/or pharmaceutical industry experience.

Required Experience and Skills:

  • Strong knowledge of chemistry and metabolism in the context of genotoxicity.

  • Understanding of non-clinical toxicology testing including genetic toxicology testing.

  • Working knowledge of ICH and regional health authority guidance. Practical experience with commonly used in silico models (e.g., Lhasa, MultiCASE, and/or Leadscope products).

  • Excellent communication (oral and written) and collaboration skills.

Preferred Experience and Skills

  • Ability to determine the sufficiency of toxicology data (e.g., genetic toxicology, repeat-dose toxicology, DART, and carcinogenicity data) identified through database searches.

  • Assigning ICH M7 classifications. Deriving exposure limits for mutagenic and non-mutagenic impurities.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/inst/1422$1533/rel-task/3001$14.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster (https://www.dol.gov/sites/dolgov/files/ofccp/regs/compliance/posters/pdf/eeopost.pdf)

EEOC GINA Supplement​

OFCCP EEO Supplement (https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCP_EEO_Supplement_Final_JRF_QA_508c.pdf)

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here (https://survey.sogosurvey.com/Survey1.aspx?k=SsQYWYYQsQRsPsPsP&lang=0) to request this role’s pay range.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

Flexible Work Arrangements:

Hybrid, On-Site, Remote Work, Telecommuting

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

1

Requisition ID: R201850

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